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OBDN

OBSIDIAN PEPTIDES

The Recomp Catalyst

5-Amino-1MQ

Inhibits NNMT → shifts methyl/NAD metabolism; proposed increase in adipocyte energy expenditure

Benefits

Body recomposition support, appetite-neutral fat loss, improved insulin sensitivity

The Fat Mobilizer

AOD-9604

Lipolysis signaling via GH fragment without GH-mediated hyperglycemia

Benefits

Fat mobilization support, gentle cut phase adjunct, no hyperglycemic effects

The Neural Shield

ARA-290

Innate-repair-receptor activation → neurovascular protection

Benefits

Nerve regeneration, microvascular stability, pain-reduction synergy with BPC

The Master Healer

BPC-157

Promotes angiogenesis, accelerates tissue regeneration, and protects gut integrity through growth-factor modulation

Benefits
  • Accelerated wound and tendon repair
  • Gut healing and protection
  • Vascular and nerve regeneration
  • Anti-inflammatory effects
Primary Systems Affected
  • Gut
  • Musculoskeletal
  • Vascular
  • Neural
Typical Dose

500 µg

Frequency

1x Daily

The Cartilage Signal

Cartalax

Bioregulatory gene modulation in chondrocytes

Benefits

Joint comfort, cartilage regeneration, mobility support

The Long-Acting Amplifier

CJC-1295

DAC-modified GHRH analog → extended half-life, sustained GH release amplification

Benefits

Sustained GH elevation, improved body composition, synergistic with Ipamorelin, convenient dosing

The Sleep Regulator

DSIP

Delta-sleep inducing peptide → circadian rhythm modulation, stress-hormone regulation

Benefits
  • Improved sleep quality and depth
  • Stress hormone normalization
  • Recovery enhancement
The Circadian Optimizer

Epitalon

Pineal‑derived peptide with proposed epigenetic effects on circadian clock genes and melatonin secretion.

Benefits

Used for improved sleep quality, stress resilience, and more coherent circadian rhythm in dysregulated schedules.

The Remodeler

GHK-Cu

Copper-dependent collagen/elastin synthesis, MMP inhibition

Benefits
  • Dermal renewal
  • Connective-tissue strength
  • Anti-inflammatory effects
  • Anti-aging crossover with tissue repair benefits
The Recovery Enhancer

Ipamorelin

Selective ghrelin receptor agonist → GH pulse without cortisol/prolactin elevation

Benefits

Muscle recovery acceleration, joint and tendon support, fat loss support

The Inflammation Brake

KPV

α-MSH fragment → NF-κB and cytokine suppression

Benefits

Calms inflammatory microenvironment, Supports epithelial recovery, Post-injury tissue repair

The Transporter

L-Carnitine

Carnitine shuttle transports long-chain fatty acids into mitochondria for beta-oxidation

Benefits

Enhanced fat oxidation, improved endurance, muscle recovery support

The Metabolic Optimizer

MOTS-C

Stress-responsive peptide that translocates to nucleus; up-regulates AMPK/FOXO programs

Benefits
  • Enhanced glucose and fatty-acid handling
  • Improved exercise adaptation
  • Metabolic flexibility enhancement
  • Weight recomposition support
Primary Systems Affected
  • Metabolic
  • Mitochondrial
  • Endocrine
Typical Dose

5-10 mg

Frequency

3-5x Weekly

Central molecule for mitochondrial energy and cellular repair

NAD+

100-500mg

NAD+ links glucose breakdown and fat oxidation to mitochondrial ATP production, and the same pool powers DNA‑repair enzymes (PARPs) and sirtuin pathways that regulate metabolism and the circadian clock.

Every cell requires NAD+
  • Transfer electrons for ATP production
  • Supplies DNA‑repair enzymes (PARPs) that continuously scan and fix everyday damage.
  • Supports sirtuin enzymes that coordinate metabolism and circadian timing.
  • Helps mitochondria maintain stable energy output during inflammation and high workload
Metabolic Function

Acting as a crucial electron carrier that powers the cell's energy-producing machinery.

Signaling Function

Serving as a master regulator of cellular health by supporting enzymes like sirtuins and PARPs.

The Neuroplasticity Catalyst

P21

CREB phosphorylation → BDNF transcription, dendritic spine growth, synaptic plasticity

Benefits
  • Enhanced learning and memory formation
  • Increased neuroplasticity
  • Cognitive recovery after injury
The Cognitive Shield

Pinealon

CNS trophic claims; proposed oligopeptide regulatory effects on brain tissue

Benefits

Cognitive support, Neuroprotection, Stress resilience

The Triple Threat

Retatrutide

Triple GLP-1 (satiety), GIP (insulinotropic/central effects), glucagon (lipolysis/EE) agonist

Benefits
  • Aggressive fat loss
  • Enhanced energy expenditure
  • Improved metabolic markers
  • Requires resistance training 3×/week
Primary Systems Affected
  • Metabolic
  • Endocrine
Typical Dose

4-12 mg

Frequency

Weekly

The Anxiolytic

Selank

Tuftsin analog → GABAergic and serotonergic modulation, enkephalin stabilization

Benefits
  • Anxiety reduction without sedation
  • Improved stress tolerance
  • Enhanced mood stability
  • Immune modulation
The Cognitive Enhancer

Semax

ACTH(4-10) analog → BDNF upregulation, D1/D2 receptor density increase, enkephalinase inhibition

Benefits
  • Enhanced focus and mental clarity
  • Improved memory consolidation
  • Neuroprotective effects
  • Stress resilience
The Appetite Regulator

Semaglutide

GLP-1R agonism with albumin-binding for extended half-life

Benefits

Weight loss support, glycemic control, CV risk reduction in high-risk cohorts

The Natural Secretagogue

Sermorelin

GHRH(1-29) analog → stimulates natural pulsatile GH release from pituitary

Benefits

Natural GH rhythm preservation, lean mass support, recovery enhancement, sleep quality improvement

The Mitochondrial Guardian

SS-31

Binds cardiolipin in inner mitochondrial membrane → stabilizes cristae, improves electron transport efficiency

Benefits
  • Reduced post-exertional malaise
  • Improved HRV and orthostatic tolerance
  • Enhanced mitochondrial function
  • Steadier work output

Cardiolipin stabilization is dose-dependent early; tapering reduces cost while keeping membrane effects

The Mobilizer

TB-500

Actin polymerization → cell migration and angiogenesis

Benefits
  • Wound-healing acceleration
  • Tissue flexibility and remodeling
  • Fibrosis reduction

Often run concurrently with BPC-157 for synergistic repair

The Fat Reducer

Tesamorelin

GHRH analog → pulsatile GH secretion, targeting visceral adipose tissue (VAT) reduction

Benefits
  • Visceral fat reduction
  • Improved body composition
  • Enhanced metabolic markers
  • Lipid profile improvement

Targets stubborn visceral fat specifically

The Dual Agonist

Tirzepatide

GLP-1 satiety/gastric delay + GIP insulinotropic/central effects

Benefits
  • Weight management
  • T2D control
  • OSA improvement with weight loss
  • Lean mass preservation with training
The Inflammation Modulator

VIP

Vasoactive Intestinal Peptide → immunomodulation, anti-inflammatory cytokine release, circadian regulation

Benefits
  • Restores vagal tone (parasympathetic "brake" on fight-or-flight)
  • Shifts immune cells from inflammatory (M1) to restorative (M2)
  • Tightens gut and lung epithelial barriers
  • Regulates circadian rhythms (sleep-wake cycles)
  • Modulates mast cell activation
Primary Systems Affected
  • Autonomic
  • Gut-Immune
  • HPA Axis

Used to treat chronic inflammatory dysautonomia, studies show Improved inflammatory markers (TGF-β1, C4a), symptomatic improvements in fatigue, cognition, dysautonomia